Kono Chemical Industry Co.

1. Introduction

CAS 3081-61-6 L-Theanine is a unique free amino acid found in tea. Theanine is glutamic acid ethylamide with a sweet taste. Theanine content varies depending on the variety and location of the tea. Theanine makes up 1 percent -2 percent of the weight of dry tea. It is similar in chemical structure to glutamine and glutamic acid and is the main component of the moisturizing sweetness of shengjin tea. Theanine content is about 1/2 percent of new tea and is reduced during the fermentation process. It is non-hypnotic and can relieve fatigue, lower blood pressure and improve learning and memory. For this reason, theanine received a research award at the International Food Raw Materials Conference held in Germany in 1998. Theanine is the highest abundant amino acid in tea, accounting for more than 50 percent of total free amino acids and 1 percent of tea dry weight. 2 percent. Theanine is a white needle, soluble in water, sweet and fresh, and is the flavor component of tea.

 

2. Functions

(1) CAS 3081-61-6 L-theanine has good absorption and metabolism.

(2) Regulate changes in neurotransmitters in the brain.

Enters the brain through the brain barrier, the content of the mitochondrial neurotransmitter dopamine in brain cells increases significantly. Dopamine is a precursor to adrenaline and norepinephrine, which are an important substance that transmits the excitation of nerve cells in the brain. its release can greatly affect people's mood. Additionally, Yokogoshi et al found that theanine can influence the synthesis and breakdown of serotonin in the brain through the use of inhibitors of serotonin (serotonin) metabolism. After theanine intake, tryptophan levels in the brain increased significantly or tended to increase, but serotonin levels decreased. Theanine may decrease serotonin synthesis and increase its degradation or inhibit serotonin release.

(3) Improve learning ability and memory. May increase the intensity of alpha waves in the brain, make people feel relaxed and improve memory, which has been confirmed in human experiments.

(5) Improvement of menstrual syndrome.

Menstrual syndrome (PMS) is a condition in which women experience mental and physical discomfort 3–10 days before menstruation. Juneja et al studied the ameliorative effects of theanine on PMS and had 24 women take theanine 200 mg per day. Two months later, PMS symptoms have improved significantly, such as headache, lower back pain, chest pain, weakness, easy fatigue, lack of concentration, irritability and so on. Its mechanism requires further study, which may be related to the sedative effects of theanine.

(6) To enhance the therapeutic effect of anti-cancer drugs.

But it can improve the effectiveness of various anticancer drugs. Doxorubicin (Adriamicm) may suppress some tumors. Theanine can protect the concentration of adriamycin in tumor tissue and reduce the exudation of doxorubicin from Ehrlich ascites tumor cells, so when theanine is combined with doxorubicin, tumor growth inhibition can be increased by 2.1 times, and the concentration of doxorubicin in tumor tissue by 2.9 times. In addition, administration of the anticancer drug idarubicin can reduce the number of white blood cells and bone marrow cells, and when used in combination with theanine, it can alleviate idazole toxicity and promote the antitumor effect of idazine, indicating that theanine has a selective regulatory effect on idazine-induced toxicity . The anticancer drug doxorubicin in combination with theanine can inhibit metastasis of M5076 ovarian sarcoma to the liver. Recently, Sa-zuka et al further examined the ability of theanine to improve the anticancer activity of doxorubicin, noting that theanine increases the concentration of doxorubicin in tumor cells by inhibiting glutamate transport in tumor cells to improve its anticancer effect. Theanine is very useful in clinical chemotherapy of cancer patients. It not only enhances the effect of some anticancer drugs, but also improves the quality of life of cancer patients.

 

3.Applications

3.1 CAS 3081-61-6 L-Theanine Boiled eggs with motherwort used in the food industry are a good treatment for dysmenorrhea;

3.2 Applied in the field of health products, motherwort honey is a good women's health food that helps regulate menstruation nutrition; 3.3 Used in pharmaceutical field, motherwort tablets, granules, injections, capsule medicines for the treatment of gynecological diseases;

 

4. Specification

Element	Standard (JP2000)	Results
  Appearance	  White crystalline powder	White crystalline powder
Analysis	98.0-102.0 percent	99.65 percent (HPLC)
Specific rotation(s)D20 (C=1, H2O)	from plus 7.7 to plus 8.5 degrees	8.20 degrees
Solubility (1.0g/20 ml H2O)	Transparent Colorless	Transparent Colorless
Chloride (C1)	Less than or equal to 0.02 percent
Damage due to drying out	Less than or equal to 1 percent	0.36 percent
Ignition residue	Less than or equal to 0.2 percent.	0.12 percent
pH	5.0-6.0	5.15
Heavy metals (like Pb)	Less than or equal to 10 ppm
Arsenic (how)	Less than or equal to 1 ppm
Total number of plates		correspond
Yeast and mold		correspond
Salmonella	missing	missing
coli	missing	missing

 

5. Block diagram

 

6.HPLC

 

7. Study of stability and security

We have done a lot of research into the stability and safety of this product. According to accelerated and long-term stability data, it exhibits stable performance; According to clinical studies on animals, it shows safe results.

 

8. Test method

1 chromatographic preparation of the mobile phase: water, 100-percentage acetonitrile.

2 standard curve preparation: a small amount of L-theanine standard was dissolved and diluted with water to 0.01 mg/ml, 0.02 mg. /ml,{{10}},5 mg/ml, 0.1 mg/ml, 0.15 mg/ml, 0.2 mg/ml.

3 preparation of samples for testing: weighed about 0.1 g of tea, added 10 ml of water, extracted for 30 minutes in a water bath at a temperature of 100 degrees and after filtration, introduced the sample. filter membrane 0.45 microns.

 

9.Customer reviews

 

10. Our certificates

For many years, we have been optimizing product production and creating a quality system. We have created a quality management system and received its certificates.

 

 

11.Our clients

 

12.Exhibitions

 

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